Nor-NOHA acetate

• CAT Number: I011468
• CAS Number: 1140844-63-8
• Molecular Formula: C9H20N4O7
• Molecular Weight: 296.28
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC(O)=O.CC(O)=O.NC(CCN/C(N)=N/O)C(O)=O

Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM).

Reference

[1] Clément Prati, et al. Arthritis Res Ther. 2012 May 30;14(3):R130.
[2] Custot J, et al. J. Am. Chem. Soc. 119, 4086-4087.