For research use only. Not for therapeutic Use.
nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism[1].
| Catalog Number | R001117 |
| CAS Number | 291758-32-2 |
| Synonyms | (2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid;dihydrochloride |
| Molecular Formula | C5H14Cl2N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C5H12N4O3.2ClH/c6-3(4(10)11)1-2-8-5(7)9-12;;/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H/t3-;;/m0../s1 |
| InChIKey | AKPIIXWPTMFQQJ-QTNFYWBSSA-N |
| SMILES | C(CN=C(N)NO)C(C(=O)O)N.Cl.Cl |
| Reference | [1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254. |
