nor-NOHA dihydrochloride

• CAT Number: R001117
• CAS Number: 291758-32-2
• Molecular Formula: C5H14Cl2N4O3
• Molecular Weight: 249.10
• Purity: ≥95%
• Synonyms: (2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid;dihydrochloride
• InChI: InChI=1S/C5H12N4O3.2ClH/c6-3(4(10)11)1-2-8-5(7)9-12;;/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H/t3-;;/m0../s1
• InChIKey: AKPIIXWPTMFQQJ-QTNFYWBSSA-N
• SMILES: C(CN=C(N)NO)C(C(=O)O)N.Cl.Cl

Nor-NOHA dihydrochloride (Cat No.: R001117) is a selective inhibitor of the enzyme arginase, which plays a role in regulating the production of nitric oxide (NO) by metabolizing the amino acid arginine. By inhibiting arginase, nor-NOHA dihydrochloride increases the availability of arginine for nitric oxide synthase, thereby enhancing nitric oxide production. This compound is commonly used in research to investigate nitric oxide’s role in various physiological and pathological processes, including vascular health, immune response, and neurodegenerative diseases.

Reference

[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.
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