Norepinephrine hydrochloride

• CAT Number: I003176
• CAS Number: 329-56-6
• Molecular Formula: C8H12ClNO3
• Molecular Weight: 205.64
• Purity: ≥95%
• Target: Others
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Norepinephrine is a catecholamine with multiple roles including those as a hormone and a neurotransmitter.Target: OthersNorepinephrine is a catecholamine with multiple roles including those as a hormone and a neurotransmitter. It is the hormone and neurotransmitter most responsible for vigilant concentration in contrast to its most chemically similar hormone, dopamine, which is most responsible for cognitive alertness. Medically it is used in those with severe hypotension. It does this by increasing vascular tone (tension of vascular smooth muscle) through α-adrenergic receptor activation. One of the most important functions of norepinephrine is its role as the neurotransmitter released from the sympathetic neurons to affect the heart. An increase in norepinephrine from the sympathetic nervous system increases the rate of contractions in the heart. As a stress hormone, norepinephrine affects parts of the brain, such as the amygdala, where attention and responses are controlled. Norepinephrine also underlies the fight-or-flight response, along with epinephrine, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. It increases the brain/’s oxygen supply [1,2 ].

Reference

[1]. Tanaka, M., et al., Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies. Eur J Pharmacol, 2000. 405(1-3): p. 397-406.

[2]. http://en.wikipedia.org/wiki/Norepinephrine