Norfloxacin

• CAT Number: A000238
• CAS Number: 70458-96-7
• Molecular Formula: C16H18FN3O3
• Molecular Weight: 319.33
• Purity: ≥95%
• Synonyms: MK-0366; 70458-96-7; Norfloxacine; Noroxin; Chibroxin; Baccidal
• Target: Antibiotic
• Solubility: Limited solubility
• Storage: -20°C
• IUPAC Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
• InChI: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
• InChIKey: OGJPXUAPXNRGGI-UHFFFAOYSA-N
• SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O

Norfloxacin（Cat No.:A000238）is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections, particularly urinary tract infections (UTIs), gastrointestinal infections, and prostatitis. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and repair, leading to bacterial cell death. With its potent activity against both Gram-positive and Gram-negative bacteria, Norfloxacin is effective in managing a wide range of infections. It is typically administered orally and is available in tablet form for convenient use in outpatient settings. Caution is advised in patients with renal impairment.

Reference

1: Li H, Chen J, Hou H, Pan H, Ma X, Yang J, Wang L, Crittenden JC. Sustained
molecular oxygen activation by solid iron doped silicon carbide under microwave
irradiation: Mechanism and application to norfloxacin degradation. Water Res.
2017 Dec 1;126:274-284. doi: 10.1016/j.watres.2017.09.001. Epub 2017 Sep 11.
PubMed PMID: 28963935.

2: Ma X, Cheng Y, Ge Y, Wu H, Li Q, Gao N, Deng J. Ultrasound-enhanced nanosized
zero-valent copper activation of hydrogen peroxide for the degradation of
norfloxacin. Ultrason Sonochem. 2018 Jan;40(Pt A):763-772. doi:
10.1016/j.ultsonch.2017.08.025. Epub 2017 Aug 24. PubMed PMID: 28946483.

3: Sidhu GS, Go A, Attar BM, Mutneja HR, Arora S, Patel SA. Rifaximin versus
norfloxacin for prevention of spontaneous bacterial peritonitis: a systematic
review. BMJ Open Gastroenterol. 2017 Jul 17;4(1):e000154. doi:
10.1136/bmjgast-2017-000154. eCollection 2017. PubMed PMID: 28944070; PubMed
Central PMCID: PMC5606119.

4: Gupta P, Patel DK, Gupta VK, Pal A, Tandon S, Darokar MP. Citral, a
monoterpenoid aldehyde interacts synergistically with norfloxacin against
methicillin resistant Staphylococcus aureus. Phytomedicine. 2017 Oct 15;34:85-96.
doi: 10.1016/j.phymed.2017.08.016. Epub 2017 Aug 17. PubMed PMID: 28899514.

5: Gómez-Hurtado I, Gimenez P, García I, Zapater P, Francés R, González-Navajas
JM, Manichanh C, Ramos JM, Bellot P, Guarner F, Such J. Norfloxacin is more
effective than Rifaximin in avoiding bacterial translocation in an animal model
of cirrhosis. Liver Int. 2017 Aug 18. doi: 10.1111/liv.13551. [Epub ahead of
print] PubMed PMID: 28834270.

6: Vignoli Muniz GS, Incio JL, Alves OC, Krambrock K, Teixeira LR, Louro SRW.
Fluorescence and electron paramagnetic resonance studies of norfloxacin and
N-donor mixed-ligand ternary copper(II) complexes: Stability and interaction with
SDS micelles. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 15;189:133-138.
doi: 10.1016/j.saa.2017.08.013. Epub 2017 Aug 5. PubMed PMID: 28806698.

7: Piplani M, Rajak H, Sharma PC. Synthesis and characterization of N-Mannich
based prodrugs of ciprofloxacin and norfloxacin: In vitro anthelmintic and
cytotoxic evaluation. J Adv Res. 2017 Jul;8(4):463-470. doi:
10.1016/j.jare.2017.06.003. Epub 2017 Jun 13. PubMed PMID: 28721301; PubMed
Central PMCID: PMC5491463.

8: Hu SB, Li L, Luo MY, Yun YF, Chang CT. Aqueous norfloxacin sonocatalytic
degradation with multilayer flower-like ZnO in the presence of peroxydisulfate.
Ultrason Sonochem. 2017 Sep;38:446-454. doi: 10.1016/j.ultsonch.2017.03.044. Epub
2017 Mar 27. PubMed PMID: 28633846.

9: Marín P, García-Martínez F, Hernándis V, Escudero E. Pharmacokinetics of
norfloxacin after intravenous, intramuscular and subcutaneous administration to
rabbits. J Vet Pharmacol Ther. 2017 Jun 11. doi: 10.1111/jvp.12422. [Epub ahead
of print] PubMed PMID: 28603857.

10: Dave V, Kushwaha K, Yadav RB, Agrawal U. Hybrid nanoparticles for the topical
delivery of norfloxacin for the effective treatment of bacterial infection
produced after burn. J Microencapsul. 2017 Jun;34(4):351-365. doi:
10.1080/02652048.2017.1337249. Epub 2017 Jul 11. PubMed PMID: 28562141.