Norlichexanthone

• CAT Number: R008558
• CAS Number: 20716-98-7
• Molecular Formula: C14H10O5
• Molecular Weight: 258.229
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 1,3,6-trihydroxy-8-methylxanthen-9-one
• InChI: InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
• InChIKey: AQZHBCDRWFMXIN-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O

Norlichexanthone (CAS 20716-98-7) has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardiovascular diseases.Norlichexanthone has antibacterial and antimalarial activities, it shows strong activity against Bacillus subtilis with IC50 in the range of 1-5uM, it also significantly inhibits the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95±1.56uM.

Reference

1.Ikeda, Megumi, et al. "Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes." Medicinal Chemistry 7.4 (2011): 250-256.
2.Chooi, Yit-Heng, et al. "SnPKS19 encodes the polyketide synthase for alternariol mycotoxin biosynthesis in the wheat pathogen Parastagonospora nodorum." Applied and environmental microbiology 81.16 (2015): 5309-5317.
3.Wang, Quan-Xin, et al. "Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp." Fitoterapia 83.1 (2012): 209-214.