For research use only. Not for therapeutic Use.
Nortriptyline (Cat No.:I008330) is a tricyclic antidepressant medication used primarily for the treatment of major depressive disorder. By increasing the levels of neurotransmitters like serotonin and norepinephrine in the brain, it helps improve mood and alleviate depressive symptoms. Nortriptyline has also been used off-label for conditions such as chronic pain, migraines, and smoking cessation.
| Catalog Number | I008330 |
| CAS Number | 72-69-5 |
| Synonyms | Nortriptyline, Allegron, Aventyl, Desitriptyline, Desmethylamitriptylin;3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine |
| Molecular Formula | C19H21N |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO, not in water |
| Storage | 4°C, protect from light |
| IUPAC Name | 3-(5,6-dihydrodibenzo[2,1-b:2/',1/'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine |
| InChI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
| InChIKey | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
| SMILES | CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
| Reference | </br>1:Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K<sup>+</sup> channels in coronary arterial smooth muscle cells. Shin SE, Li H, Kim HS, Kim HW, Seo MS, Ha KS, Han ET, Hong SH, Firth AL, Choi IW, Bae YM, Park WS.Korean J Physiol Pharmacol. 2017 Mar;21(2):225-232. doi: 10.4196/kjpp.2017.21.2.225. Epub 2017 Feb 21. PMID: 28280416 Free PMC Article</br>2:In vitro effects of caffeic acid, nortriptyline, precocene I and quercetin against Rhipicephalus annulatus (Acari: Ixodidae). Ravindran R, Chithra ND, Deepa PE, Ajithkumar KG, Chandrasekhar L, Sreelekha K, Nair SN, Juliet S, Ghosh S.Exp Appl Acarol. 2017 Feb;71(2):183-193. doi: 10.1007/s10493-017-0105-2. Epub 2017 Jan 21. PMID: 28110429 </br>3:Erratum to /A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples/ [Spectrochim. Acta A Mol. Biomol. Spectrosc. 168, 2016, 235-243]. Farnoudiyan-Habibi A, Massoumi B, Jaymand M.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Apr 15;177:14. doi: 10.1016/j.saa.2017.01.025. Epub 2017 Jan 16. No abstract available. PMID: 28109963 </br>4:Interference in Na+ measurements on the Siemens RAPIDPoint® 500 after nortriptyline intoxication: a case report. van der Hagen EA, Smeekens KC, van /’t Veer NE, Boonen KJ, Ermens AA.Clin Chem Lab Med. 2017 Jan 18. pii: /j/cclm.ahead-of-print/cclm-2016-0890/cclm-2016-0890.xml. doi: 10.1515/cclm-2016-0890. [Epub ahead of print] No abstract available. PMID: 28099119 </br>5:A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy. Berm EJ, Gout-Zwart JJ, Luttjeboer J, Wilffert B, Postma MJ.PLoS One. 2016 Dec 29;11(12):e0169065. doi: 10.1371/journal.pone.0169065. eCollection 2016. PMID: 28033366 Free PMC Article</br>6:Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline. Marcon M, Herrmann AP, Mocelin R, Rambo CL, Koakoski G, Abreu MS, Conterato GM, Kist LW, Bogo MR, Zanatta L, Barcellos LJ, Piato AL.Psychopharmacology (Berl). 2016 Oct;233(21-22):3815-3824. Epub 2016 Aug 25. PMID: 27562666 </br>7:A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples. Farnoudian-Habibi A, Massoumi B, Jaymand M.Spectrochim Acta A Mol Biomol Spectrosc. 2016 Nov 5;168:235-43. doi: 10.1016/j.saa.2016.06.013. Epub 2016 Jun 7. No abstract available. PMID: 27294553 </br>8:Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion. Yazdani I, Ghazi-Khansari M, Saeedi Saravi SS, Nobakht M, Majdani R, Rezayat SM, Mousavi SE, Yari A, Dehpour AR.Andrologia. 2017 Mar;49(2). doi: 10.1111/and.12605. Epub 2016 May 5. PMID: 27147301 </br>9:Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry. Berm E, Kok R, Hak E, Wilffert B.Pharmacopsychiatry. 2016 Sep;49(5):186-190. Epub 2016 Apr 21. PMID: 27101231 </br>10:Inhibition of Efavirenz Metabolism by Sertraline and Nortriptyline and Their Effect on Efavirenz Plasma Concentrations. Melis V, Usach I, Gandía P, Peris JE.Antimicrob Agents Chemother. 2015 Dec 7;60(2):1022-8. doi: 10.1128/AAC.02129-15. Print 2016 Feb. PMID: 26643342 Free PMC Article |
