Norverapamil hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I004551
  • CAS Number: 67812-42-4
  • Molecular Formula: C26H36N2O4 • HCl
  • Molecular Weight: 477
  • Purity: ≥95%
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<p style=/line-height:25px/>Norverapamil is a calcium channel blocker, it is the main active metabolite of verapamil.<br>In vitro: Norverapamil is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil.[1] Norverapamil (NOR) is the major metabolite and shows approximately 20% of the efficacy of VER with regard to the vasodilation effect, but shows no antiarrhythmic activity. [2] Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic. [3]</p>


Catalog Number I004551
CAS Number 67812-42-4
Synonyms

D 591

Molecular Formula C26H36N2O4 • HCl
Purity ≥95%
Target Neuronal Signaling
Solubility DMSO ≥ 31 mg/mL
Storage -20°C
InChIKey OEAFTRIDBHSJDC-UHFFFAOYSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Adams KN et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.

<br>[2]. Singhal P et al. Enantiomeric separation of verapamil and its active metabolite, norverapamil, and simultaneous quantification in human plasma by LC-ESI-MS-MS. J Chromatogr Sci. 2012 Oct;50(9):839-48.

<br>[3]. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.

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