Norverapamil hydrochloride

• CAT Number: I004551
• CAS Number: 67812-42-4
• Molecular Formula: C26H36N2O4 • HCl
• Molecular Weight: 477.00
• Purity: ≥95%
• Synonyms: D 591
• Target: Neuronal Signaling
• Solubility: DMSO ≥ 31 mg/mL
• Storage: -20°C
• IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile;hydrochloride
• InChI: InChI=1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H
• InChIKey: OEAFTRIDBHSJDC-UHFFFAOYSA-N
• SMILES: CC(C)C(CCCNCCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

Norverapamil hydrochloride（Cat No.:I004551）is the major active metabolite of verapamil, a calcium channel blocker used to treat hypertension, angina, and certain arrhythmias. It has similar pharmacological effects as verapamil but with a longer half-life. Norverapamil works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation, reduced heart rate, and decreased myocardial oxygen demand. This helps to lower blood pressure and alleviate angina. Norverapamil is often measured in pharmacokinetic studies to assess verapamil’s therapeutic effects and metabolism in the body.