Nosiheptide

• CAT Number: R017657
• CAS Number: 56377-79-8
• Molecular Formula: C51H43N13O12S6
• Molecular Weight: 1222.40
• Purity: ≥95%
• Synonyms: Nosiheptide; 30,32-Imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontine nosiheptide deriv.; Multhiomycin; Multiomycin; NSC 307240; Primofax
• Target: Bacterial
• Storage: -20°C

Nosiheptide（Cat No.:R017657）is a thiopeptide antibiotic derived from Streptomyces species, known for its strong antibacterial activity, particularly against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile. It works by inhibiting bacterial protein synthesis, binding to the 50S ribosomal subunit, which disrupts peptide elongation. Nosiheptide is primarily used in veterinary medicine as a growth promoter and to control infections in livestock, though its potential in human medicine is under investigation due to its low resistance development. Its efficacy and stability make it a valuable tool in animal health management.

Reference

A new antibiotic, multhiomycin. Tanaka T. et al. J. Antibiot. 1970, 23, 231.

Identity of multhiomycin with nosiheptide. Endo T. and Yonehara H. J. Antibiot, 1978, 31, 623.

Thiostrepton group of antibiotics. Pestka S. and Bodley J. Antibiotics. III. 1975, 551-573 ed. Corcoran J.W. & Harn F.E., Springer-Verlag, New York.

Activity of the thiopeptide antibiotic, nosiheptide, against contemporary strains of methicillin-resistant Staphylococcus aureus. Haste N.M. et al. J. Antibiot. 2012, 65, 593.