For research use only. Not for therapeutic Use.
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect[1][2].
| Catalog Number | I045300 |
| CAS Number | 56491-86-2 |
| Synonyms | 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid |
| Molecular Formula | C12H21N3O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H21N3O6/c16-10(17)7-13-1-2-14(8-11(18)19)5-6-15(4-3-13)9-12(20)21/h1-9H2,(H,16,17)(H,18,19)(H,20,21) |
| InChIKey | JHALWMSZGCVVEM-UHFFFAOYSA-N |
| SMILES | C1CN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O |
| Reference | [1]. Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. [2]. Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. |
