For research use only. Not for therapeutic Use.
Nourseothricin sulfate（Cat No.:R000838）is a broad-spectrum aminoglycoside antibiotic used primarily in microbiological research and agriculture. It inhibits protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing bacterial growth. Nourseothricin sulfate is particularly effective against Gram-positive bacteria and certain fungi. In laboratory settings, it is commonly employed as a selectable marker in genetic engineering and recombinant DNA technology. Its antimicrobial properties make it useful for maintaining antibiotic resistance in transformed organisms, ensuring the expression of recombinant genes. Nourseothricin sulfate is also utilized in plant transformation studies.
| Catalog Number | R000838 |
| CAS Number | 96736-11-7 |
| Synonyms | streptothricin sulfate |
| Molecular Formula | C44H82N18O21S |
| Purity | ≥95% |
| Target | Fungal |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| Related CAS | 56089-12-4(free base) |
| IUPAC Name | [(2R,3R,4S,5R,6R)-6-[[(3aS,7R,7aS)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3S)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate;sulfuric acid |
| InChI | InChI=1S/C19H34N8O8.H2O4S/c20-3-1-2-7(21)4-10(30)24-13-14(31)15(35-18(22)33)9(6-28)34-17(13)27-19-25-11-8(29)5-23-16(32)12(11)26-19;1-5(2,3)4/h7-9,11-15,17,28-29,31H,1-6,20-21H2,(H2,22,33)(H,23,32)(H,24,30)(H2,25,26,27);(H2,1,2,3,4)/t7-,8+,9+,11+,12-,13+,14-,15-,17+;/m0./s1 |
| InChIKey | UDVWKDBCMFLRQW-TWRCRAKCSA-N |
| SMILES | C1[C@H]([C@@H]2[C@@H](C(=O)N1)N=C(N2)N[C@H]3[C@@H]([C@@H]([C@H]([C@H](O3)CO)OC(=O)N)O)NC(=O)C[C@H](CCCN)N)O.OS(=O)(=O)O |
| Reference | Kochupurakkal, B. S., & Iglehart, J. D. (2013). Nourseothricin N-Acetyl Transferase: A positive selection marker for mammalian cells. PLoS ONE, 8(7), e68509. doi:10.1371/journal.pone.0068509<br /> |
