Novobiocin Sodium Salt

• CAT Number: A000332
• CAS Number: 1476-53-5
• Molecular Formula: C31H35N1NaO11
• Molecular Weight: 634.61
• Purity: ≥95%
• Target: Apoptosis
• Storage: 3 years -20C powder
• IUPAC Name: sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
• InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
• InChIKey: WWPRGAYLRGSOSU-UHFFFAOYSA-M
• SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]

Novobiocin Sodium Salt（Cat No.:A000332）is an antibiotic derived from Streptomyces species, primarily effective against Gram-positive bacteria. It works by inhibiting bacterial DNA gyrase, disrupting DNA replication and transcription processes. Novobiocin is commonly used in research to study bacterial DNA synthesis and as a selection agent in cell cultures. Its applications extend to exploring mechanisms of antibiotic resistance, particularly for resistant Staphylococcus strains. Though rarely used clinically due to resistance and newer options, Novobiocin Sodium Salt remains significant in laboratory research for bacterial physiology and genetic studies.

Reference

1.Brown, Patrick O., and Craig L. Peebles. /Energy Coupling in DNA Gyrase and the Mechanism of Action of Novobiocin./ PNAS 75.2 (1978): 4838-842. Web. 21 Aug. 2012.
2.Benjama and Charkaoui, 1997, Control of Bacillus contaminating Date palm tissue in micro- propagation using antibiotics. Pathogen and microbial contamination management in micro- propagation. Kluwer academic publishers.