NPAS3-IN-1

• CAT Number: I040638
• CAS Number: 2207-44-5
• Molecular Formula: C10H5N3O2S3
• Molecular Weight: 295.36
• Purity: ≥95%
• Synonyms: 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole
• InChI: InChI=1S/C10H5N3O2S3/c14-13(15)8-5-11-9(17-8)18-10-12-6-3-1-2-4-7(6)16-10/h1-5H
• InChIKey: UHBFMJAKLZGVDS-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=C(S2)SC3=NC=C(S3)[N+](=O)[O-]

NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization and regulates NPAS3 transcription by disrupting the heterodimerization of NPAS3 with ARNT at the cellular level[1].

Reference

[1]. Li P, et al. Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT. Bioorg Chem. 2023 Oct;139:106676.
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