For research use only. Not for therapeutic Use.
NPBA (N-(4-Nitrophenyl)butanamide) (Cat No.: I040183) is an organic compound commonly used in chemical synthesis and as an intermediate in the production of pharmaceutical agents. The nitro group on the aromatic ring provides useful reactivity for reactions such as nucleophilic substitution and reduction. NPBA is particularly valuable in the development of bioactive molecules and has been explored for its potential applications in drug discovery, especially in modifying the pharmacological properties of certain drug candidates. Its role in medicinal chemistry continues to be investigated for various therapeutic areas.
| CAS Number | 524033-40-7 |
| Synonyms | N-[2-[4-nitro-2-(trifluoromethyl)anilino]ethyl]benzamide |
| Molecular Formula | C16H14F3N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14F3N3O3/c17-16(18,19)13-10-12(22(24)25)6-7-14(13)20-8-9-21-15(23)11-4-2-1-3-5-11/h1-7,10,20H,8-9H2,(H,21,23) |
| InChIKey | LUJDPMMSYZQCHA-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)NCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(F)(F)F |
| Reference | [1]. Fuyun Tian, et al. A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues. Mol Pharmacol. 2019 Jul;96(1):26-35. [2]. Yuanxing Zhi, et al. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec:218:115894. |
