NPS-2143 hydrochloride

• CAT Number: I003150
• CAS Number: 324523-20-8
• Molecular Formula: C24H25ClN2O2 • HCl
• Molecular Weight: 445.40
• Purity: ≥95%
• Synonyms: 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride
• Target: CaSR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 43 nM(for Ca2+ receptor)
• InChI: InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
• InChIKey: ZEBNDUQLNGYBNL-VEIFNGETSA-N
• SMILES: CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl

NPS-2143 hydrochloride（Cat No.:I003150）is a selective antagonist of the calcium-sensing receptor (CaSR), which plays a key role in regulating calcium levels in the body. By blocking the CaSR, NPS-2143 can modulate calcium homeostasis, making it a potential therapeutic agent in conditions related to calcium imbalance, such as hyperparathyroidism and certain kidney diseases. It has also been investigated for its potential neuroprotective effects, particularly in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Research on NPS-2143 is ongoing, and its full clinical applications and safety profile are yet to be determined.