NPS-2143

• CAT Number: I002966
• CAS Number: 284035-33-2
• Molecular Formula: C24H25ClN2O2
• Molecular Weight: 408.93
• Purity: ≥95%
• Synonyms: 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
• Target: CaSR
• Solubility: DMSO ≥80mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Storage: 3 years -20C powder
• IC50: 43 nM(for Ca2+ receptor)
• InChI: InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
• InChIKey: PZUJQWHTIRWCID-HXUWFJFHSA-N
• SMILES: CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O

NPS-2143（Cat No.:I002966）is a selective antagonist of the calcium-sensing receptor (CaSR), a G protein-coupled receptor involved in regulating extracellular calcium levels. By blocking CaSR, NPS-2143 can modulate calcium homeostasis and is being explored for potential therapeutic applications in conditions related to calcium dysregulation, such as hyperparathyroidism and certain bone disorders. It has also been studied for its effects on parathyroid hormone (PTH) secretion and its role in controlling calcium and phosphate balance. Research on NPS-2143 continues to explore its safety, efficacy, and possible clinical applications in managing calcium-related diseases.