For research use only. Not for therapeutic Use.
NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].
NPY5RA-972(p.o., 10.5 mg/kg) has a Tmax value of 1 hour in rats, a Cmax of 35 μM, a half-life of 6.4 hours, and a total plasma concentration of greater than 3 μM/h even 24 hours after administration[1].
NPY5RA-972 (p.o., 1-10 mg/kg) inhibits food intake elicited by a selective NPY Y5 receptor agonist, but has no effect on food intake or body weight in freely-fed Wistar rats or diet-obese rats Influence[1].
| Catalog Number | I010806 |
| CAS Number | 439861-56-0 |
| Synonyms | N-(4-methyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide |
| Molecular Formula | C21H25N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H25N3O2/c1-14(2)24-18-7-5-4-6-16(18)20-15(3)17(8-9-19(20)24)22-21(25)23-10-12-26-13-11-23/h4-9,14H,10-13H2,1-3H3,(H,22,25) |
| InChIKey | ZNFMHLDBJPAFEQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC2=C1C3=CC=CC=C3N2C(C)C)NC(=O)N4CCOCC4 |
| Reference | [1]. Andrew V Turnbull, et al. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. 2002 Aug;51(8):2441-9. |
