NQDI-1

For research use only. Not for therapeutic Use.

  • CAT Number: I002284
  • CAS Number: 175026-96-7
  • Molecular Formula: C₁₉H₁₃NO₄
  • Molecular Weight: 319.31
  • Purity: ≥95%
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NQDI-1 (Cat No.:I002284) is a small-molecule inhibitor that targets the interaction between the apoptosis signal-regulating kinase 1 (ASK1) and its regulatory protein, thioredoxin. By disrupting this interaction, NQDI-1 inhibits the activation of ASK1, which is involved in cellular stress responses and inflammation. NQDI-1 has shown potential in various disease models, including neurodegenerative diseases, ischemic injury, and inflammation-related disorders. It is known for its ability to reduce oxidative stress, promote cell survival, and attenuate inflammatory responses. NQDI-1 represents a promising tool for further understanding the role of ASK1 signaling and may have therapeutic applications in treating certain diseases associated with oxidative stress and inflammation.


Catalog Number I002284
CAS Number 175026-96-7
Synonyms

ethyl 2,7-dioxo-3,7-dihydro-2H-naphtho[1,2,3-de]quinoline-1-carboxylate

Molecular Formula C₁₉H₁₃NO₄
Purity ≥95%
Target ASK1
Solubility DMSO: ≤ 10 mg/mL
Storage Store at 4°C
IC50 500 nM (Ki)
IUPAC Name ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylate
InChI InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
InChIKey UFJGFNHRMPMALC-UHFFFAOYSA-N
SMILES CCOC(=O)C1=C2C3=CC=CC=C3C(=O)C4=C2C(=CC=C4)NC1=O
Reference

</br>1:NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death. Hao H, Li S, Tang H, Liu B, Cai Y, Shi C, Xiao X.Mol Med Rep. 2016 Jun;13(6):4585-92. doi: 10.3892/mmr.2016.5123. Epub 2016 Apr 13. PMID: 27081917 Free PMC Article</br>2:NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. El Eter E.Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):179-86. PMID: 23952292

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