For research use only. Not for therapeutic Use.
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].
| Catalog Number | I019069 |
| CAS Number | 2304503-05-5 |
| Synonyms | 6,7-difluoro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| Molecular Formula | C13H2F2N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C13H2F2N4O/c14-7-1-5-6(2-8(7)15)13(20)12-11(5)18-9(3-16)10(4-17)19-12/h1-2H |
| InChIKey | PZUSGRHVYDQLHR-UHFFFAOYSA-N |
| SMILES | C1=C2C(=CC(=C1F)F)C(=O)C3=NC(=C(N=C23)C#N)C#N |
| Reference | [1]. Wu X, et al. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61(24):11280-11297. |
