For research use only. Not for therapeutic Use.
NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].
| Catalog Number | I040075 |
| CAS Number | 452087-38-6 |
| Synonyms | N-[2-(3,4-dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine |
| Molecular Formula | C17H19N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H19N3O2S/c1-11-8-13-16(19-10-20-17(13)23-11)18-7-6-12-4-5-14(21-2)15(9-12)22-3/h4-5,8-10H,6-7H2,1-3H3,(H,18,19,20) |
| InChIKey | CRLNCEZRMMLCIH-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(N=CN=C2S1)NCCC3=CC(=C(C=C3)OC)OC |
| Reference | [1]. Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031. |
