Nrf2-Activator-12G

• CAT Number: I033535
• CAS Number: 1554271-18-9
• Molecular Formula: C15H13ClO3S
• Molecular Weight: 308.78
• Purity: ≥95%
• Synonyms: 1-chloro-2-[(E)-2-(2-methoxyphenyl)sulfonylethenyl]benzene
• InChI: InChI=1S/C15H13ClO3S/c1-19-14-8-4-5-9-15(14)20(17,18)11-10-12-6-2-3-7-13(12)16/h2-11H,1H3/b11-10+
• InChIKey: KVDYSDOWSIXKPB-ZHACJKMWSA-N
• SMILES: COC1=CC=CC=C1S(=O)(=O)C=CC2=CC=CC=C2Cl

Nrf2-Activator-12G (Cat No.: I033535) is a synthetic compound designed to activate nuclear factor erythroid 2–related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidant and detoxification responses. By promoting Nrf2 translocation into the nucleus, this activator enhances the expression of cytoprotective genes involved in oxidative stress defense, inflammation modulation, and metabolic regulation. Nrf2-Activator-12G is primarily used in research to explore therapeutic strategies for diseases associated with oxidative damage, such as neurodegenerative disorders, cancer, and chronic inflammatory conditions, supporting cellular resilience and homeostasis.

Reference

[1]. Woo SY, et al. Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson’s disease therapy. J Med Chem. 2014 Feb 27;57(4):1473-87.
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