Nrf2-ARE/hMAO-B/QR2 modulator 1

• CAT Number: I043880
• Molecular Formula: C14H12N2O3
• Molecular Weight: 256.26
• Purity: ≥95%
• Synonyms: 5-[(E)-2-(4-methoxyphenyl)ethenyl]-3-prop-2-ynyl-1,3,4-oxadiazol-2-one
• InChI: InChI=1S/C14H12N2O3/c1-3-10-16-14(17)19-13(15-16)9-6-11-4-7-12(18-2)8-5-11/h1,4-9H,10H2,2H3/b9-6+
• InChIKey: SFKGQKWKUGEJCM-RMKNXTFCSA-N
• SMILES: COC1=CC=C(C=C1)C=CC2=NN(C(=O)O2)CC#C

Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC50s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (OA)) significantly increases the cell viability of OA-treated rat primary cortical neurons to 70-80%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (10 μM) shows the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), as well as the greatest distance of cell migration in mice NSCs which isolated from SGZ[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 72 hours) confers neuroprotection and reduces cell death, decreasing ROS production in mice hippocampal slices exposed to OA[1].

Reference

[1]. Herrera-Arozamena C, Estrada-Valencia M, López-Caballero P, et al. Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. J Med Chem. 2022;65(6):4727-4751.
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