For research use only. Not for therapeutic Use.
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)[1].
Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation[1].
Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell[1].
Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro[1].
Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax[1].
Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs[1].
| Catalog Number | I018791 |
| CAS Number | 1610022-76-8 |
| Synonyms | 2-[(4-tert-butylphenyl)methyl]-5-(4-chlorophenyl)-N-hydroxypyrazole-3-carboxamide |
| Molecular Formula | C21H22ClN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22ClN3O2/c1-21(2,3)16-8-4-14(5-9-16)13-25-19(20(26)24-27)12-18(23-25)15-6-10-17(22)11-7-15/h4-12,27H,13H2,1-3H3,(H,24,26) |
| InChIKey | ZFDMUUNGVLREEC-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Cl)C(=O)NO |
| Reference | [1]. Zhang J, et al. Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget. 2017 Jan 31;8(5):7625-7636. |
