For research use only. Not for therapeutic Use.
NRX-1532 is a small molecule enhancer of β-catenin:β-TrCP interaction.
| Catalog Number | I043868 |
| Synonyms | 2-oxo-N-[3-(1H-pyrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide |
| Molecular Formula | C16H11F3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H11F3N4O2/c17-16(18,19)13-5-4-11(15(25)22-13)14(24)21-10-3-1-2-9(8-10)12-6-7-20-23-12/h1-8H,(H,20,23)(H,21,24)(H,22,25) |
| InChIKey | KRFAUNDDLPKBNF-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)NC(=O)C2=CC=C(NC2=O)C(F)(F)F)C3=CC=NN3 |
| Reference | [1]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. |
