For research use only. Not for therapeutic Use.
NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders.
| Catalog Number | I043867 |
| CAS Number | 2763260-30-4 |
| Synonyms | 2-oxo-N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide |
| Molecular Formula | C14H9F3N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H9F3N6O2/c15-14(16,17)10-5-4-9(13(25)19-10)12(24)18-8-3-1-2-7(6-8)11-20-22-23-21-11/h1-6H,(H,18,24)(H,19,25)(H,20,21,22,23) |
| InChIKey | IAVMZDPIQIVLOG-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)NC(=O)C2=CC=C(NC2=O)C(F)(F)F)C3=NNN=N3 |
| Reference | [1]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. |
