For research use only. Not for therapeutic Use.
NS-2(CAT: I008362), with its potential as a free aldehyde trapper, holds promise for addressing uveitis and fatty aldehyde dehydrogenase deficiency. By efficiently capturing free aldehydes, NS-2 may mitigate oxidative stress and cellular damage, offering a potential therapeutic avenue for managing uveitis, an inflammatory eye condition. Furthermore, its application in fatty aldehyde dehydrogenase deficiency could contribute to restoring proper aldehyde metabolism and reducing related pathological effects.
| Catalog Number | I008362 |
| CAS Number | 916056-79-6 |
| Synonyms | NS-2; NS2; NS 2;2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol |
| Molecular Formula | C12H13ClN2O |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol |
| InChI | InChI=1S/C12H13ClN2O/c1-12(2,16)11-9(14)6-7-5-8(13)3-4-10(7)15-11/h3-6,16H,14H2,1-2H3 |
| InChIKey | GUHFUVLKYSQIOQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=C(C=C2C=C(C=CC2=N1)Cl)N)O |
| Reference | </br>1:Implementation of WirelessHART in the NS-2 simulator and validation of its correctness. Zand P, Mathews E, Havinga P, Stojanovski S, Sisinni E, Ferrari P.Sensors (Basel). 2014 May 16;14(5):8633-68. doi: 10.3390/s140508633. PMID: 24841245 Free PMC Article</br>2:Highly thermostable and pH-stable cellulases from Aspergillus niger NS-2: properties and application for cellulose hydrolysis. Bansal N, Janveja C, Tewari R, Soni R, Soni SK.Appl Biochem Biotechnol. 2014 Jan;172(1):141-56. doi: 10.1007/s12010-013-0511-9. Epub 2013 Sep 20. PMID: 24052336 </br>3:Production of cellulases from Aspergillus niger NS-2 in solid state fermentation on agricultural and kitchen waste residues. Bansal N, Tewari R, Soni R, Soni SK.Waste Manag. 2012 Jul;32(7):1341-6. doi: 10.1016/j.wasman.2012.03.006. Epub 2012 Apr 12. PMID: 22503148 </br>4:The non-structural protein NS-2 of Bombyx mori parvo-like virus is localized to the nuclear membrane. Wang F, Hu Z, He Y, Li G, Kong J, Cao J, Chen K, Yao Q.Curr Microbiol. 2011 Jul;63(1):8-15. doi: 10.1007/s00284-011-9933-1. Epub 2011 Apr 11. PMID: 21479931 </br>5:Flash and continuous photolysis studies of the thionitrosyl complex Cr(CH3CN)5(NS)2+ and the nitric oxide analogs: reactions of nitrogen monosulfide in solution. Dethlefsen JW, Hedegård ED, Rimmer RD, Ford PC, Døssing A.Inorg Chem. 2009 Jan 5;48(1):231-8. doi: 10.1021/ic8016936. PMID: 19032042 </br>6:Isolation of an aerobic denitrifying bacterial strain NS-2 from the activated sludge of piggery wastewater treatment systems in Taiwan possessing denitrification under 92% oxygen atmosphere. Su JJ, Liu BY, Lin J, Yang CP.J Appl Microbiol. 2001 Nov;91(5):853-60. PMID: 11722663 Free Article</br>7:Synthesis of Pyridine NS(2) Ligands Incorporating 1-Methoxycarbonyl-2-thio(o-carborane). Are They a Route to /Carboranethiophene/ Compounds? Teixidor F, Anglès P, Viñas C.Inorg Chem. 1999 Aug 9;38(16):3605-3608. PMID: 11671115 </br>8:Copper(I) Complexes with a NS(2)-Macrocyclic Ligand Bearing a Pendant Naphthyl Group: Structures of {N-[2-(1-Naphthyl)ethyl]-1-aza-4,8-dithiacyclodecane}copper(I)-Ligand, where Ligand = eta(2)-Naphthalene, Acetonitrile, or Triphenylphosphine. Conry RR, Striejewske WS, Tipton AA.Inorg Chem. 1999 Jun 14;38(12):2833-2843. PMID: 11671028 </br>9:Comparative study of NS(2)(S-aryl) pyridine-based dithia-containing ligands with different substituent groups. Reactivity toward Cu(II) and Ru(II). Teixidor F, Anglès P, Viñas C, Kivekäs R, Sillanpää R.Inorg Chem. 2001 Jul 30;40(16):4010-5. PMID: 11466061 </br>10:Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine. Komori S, Sawanobori T, Tamura K, Kane KA, Parratt JR.Jpn J Pharmacol. 1994 Jul;65(3):193-200. PMID: 7799519 Free Article |
