For research use only. Not for therapeutic Use.
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation.
| Catalog Number | R058694 |
| CAS Number | 204326-43-2 |
| Synonyms | 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one; |
| Molecular Formula | C9H5BrN2O3 |
| Purity | ≥95% |
| Target | Guanylate Cyclase |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4C |
| IUPAC Name | 8-bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one |
| InChI | InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2 |
| InChIKey | MUDRLQRJCGJJTB-UHFFFAOYSA-N |
| SMILES | C1C2=NOC(=O)N2C3=C(O1)C=CC(=C3)Br |
| Reference | </br>1:The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Morbidelli L, Pyriochou A, Filippi S, Vasileiadis I, Roussos C, Zhou Z, Loutrari H, Waltenberger J, Stössel A, Giannis A, Ziche M, Papapetropoulos A.Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R824-32. doi: 10.1152/ajpregu.00222.2009. Epub 2009 Dec 23. PMID: 20032260 Free Article</br>2:Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Olesen SP, Drejer J, Axelsson O, Moldt P, Bang L, Nielsen-Kudsk JE, Busse R, Mülsch A.Br J Pharmacol. 1998 Jan;123(2):299-309. PMID: 9489619 Free PMC Article |
