NS-220

• CAT Number: I008363
• CAS Number: 377731-45-8
• Molecular Formula: C21H27NO5
• Molecular Weight: 373.45
• Purity: ≥95%
• Synonyms: NS-220; NS 220; NS220; LS-191458.;(2s,5s)-2-methyl-5-(4-(5-methyl-2-(p-tolyl)oxazol-4-yl)butyl)-1,3-dioxane-2-carboxylic acid
• Solubility: Soluble in DMSO
• Storage: Store at RT
• IUPAC Name: 2-methyl-5-[4-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]butyl]-1,3-dioxane-2-carboxylic acid
• InChI: InChI=1S/C21H27NO5/c1-14-8-10-17(11-9-14)19-22-18(15(2)27-19)7-5-4-6-16-12-25-21(3,20(23)24)26-13-16/h8-11,16H,4-7,12-13H2,1-3H3,(H,23,24)/t16-,21+
• InChIKey: IMYPSTHZBIWMNA-NBEIKUQISA-N
• SMILES: O=C([C@@]1(C)OC[C@@H](CCCCC2=C(C)OC(C3=CC=C(C)C=C3)=N2)CO1)O

NS-220(CAT: I008363) is a novel and selective peroxisome proliferator-activated receptor alpha (PPARα) agonist that plays a crucial role in regulating lipid and glucose metabolism. By activating PPARα, NS-220 enhances the expression of genes involved in fatty acid oxidation, leading to a significant reduction in plasma triglyceride and glucose levels. In preclinical studies with KK-Ay mice, a model for type 2 diabetes and obesity, NS-220 effectively improves lipoprotein profiles, suggesting its therapeutic potential in treating metabolic disorders such as dyslipidemia, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD).