For research use only. Not for therapeutic Use.
NS-3-008(Cat No.:I017170) is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with inhibitory effects on Hsd17b4 and Stat5 signaling. It has demonstrated potential benefits in a mouse model of chronic kidney disease, including decreased levels of G0s2 and Ccl2 mRNA, reduced phosphorylation of Stat5 and p65 protein, lower SUN concentrations, decreased renal caspase 3/7 activity, and reduced F4/80-positive area and F4/80 protein levels. These findings suggest that NS-3-008 may have therapeutic implications for chronic kidney disease, but further research and clinical studies are necessary to validate its efficacy and safety in human patients.
| Catalog Number | I017170 |
| CAS Number | 1172854-54-4 |
| Molecular Formula | C₁₄H₂₄ClN₃ |
| Purity | ≥95% |
| IUPAC Name | 2-benzyl-1-hexylguanidine;hydrochloride |
| InChI | InChI=1S/C14H23N3.ClH/c1-2-3-4-8-11-16-14(15)17-12-13-9-6-5-7-10-13;/h5-7,9-10H,2-4,8,11-12H2,1H3,(H3,15,16,17);1H |
| InChIKey | UMIOAATZOCKZTH-UHFFFAOYSA-N |
| SMILES | CCCCCCNC(=NCC1=CC=CC=C1)N.Cl |
| Reference | [1]. Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273. |
