NS 3623

• CAT Number: R042489
• CAS Number: 343630-41-1
• Molecular Formula: C15H10BrF3N6O
• Molecular Weight: 427.19
• Purity: ≥95%
• Synonyms: 1-(3-Trifluoromethylphenyl)-3-[2-(1H-tetrazol-5-yl)-4-bromophenyl]urea; N-[4-Bromo-2-(2H-tetrazol-5-yl)phenyl]-N’-[3-(trifluoromethyl)phenyl]-urea
• Target: Potassium Channel
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4℃
• IUPAC Name: 1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
• InChI: InChI=1S/C15H10BrF3N6O/c16-9-4-5-12(11(7-9)13-22-24-25-23-13)21-14(26)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H2,20,21,26)(H,22,23,24,25)
• InChIKey: JXPULDIATMTIIN-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F

NS 3623 is a selective small molecule inhibitor that targets NADPH oxidase 4 (NOX4), an enzyme involved in the production of reactive oxygen species (ROS). It has been studied for its potential therapeutic applications in diseases where oxidative stress plays a critical role, such as fibrosis, chronic obstructive pulmonary disease (COPD), and cancer. By inhibiting NOX4, NS 3623 may help reduce inflammation and tissue damage, offering promise for managing oxidative stress-related conditions and improving outcomes in affected patients.