NS-398

• CAT Number: I000945
• CAS Number: 123653-11-2
• Molecular Formula: C13H18N2O5S
• Molecular Weight: 314.36
• Purity: ≥95%
• Synonyms: N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide
• Target: COX
• Solubility: 10 mM in DMSO
• Storage: Room Temperature
• IC50: 3.8 μM
• IUPAC Name: N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
• InChI: InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
• InChIKey: KTDZCOWXCWUPEO-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2

NS-398 (Cat No.:I000945) is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily used in research to investigate the role of COX-2 in inflammation and cancer. Unlike non-selective NSAIDs, NS-398 selectively inhibits COX-2, an enzyme involved in the production of pro-inflammatory prostaglandins, without significantly affecting COX-1, which protects the stomach lining. This selectivity reduces the risk of gastrointestinal side effects. NS-398 has been explored for its potential anti-inflammatory, analgesic, and anticancer effects, especially in reducing tumor growth and inflammation.