For research use only. Not for therapeutic Use.
NS13001(CAT: I008360) operates as a selective modulator of SK2/3 channels, holding promise as a potential therapeutic intervention for the treatment of Spinocerebellar Ataxia Type 2 (SCA2). This compound’s specific interaction with SK2/3 channels suggests its capacity to influence neuronal excitability and calcium signaling. By targeting these channels, NS13001 has implications for regulating cellular processes related to SCA2 pathology. Its role as a potential therapeutic agent in managing SCA2 highlights its significance in neurodegenerative disorder research and potentially paves the way for innovative therapeutic strategies.
| Catalog Number | I008360 |
| CAS Number | 1063331-94-1 |
| Synonyms | NS13001; NS 13001; NS-13001.;N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine |
| Molecular Formula | C17H16ClN7 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine |
| InChI | InChI=1S/C17H16ClN7/c1-10-8-11(2)25(23-10)17-21-15(14-16(22-17)24(3)9-19-14)20-13-6-4-12(18)5-7-13/h4-9H,1-3H3,(H,20,21,22) |
| InChIKey | DVQOPNIPUIOXHU-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1C2=NC3=C(C(=N2)NC4=CC=C(C=C4)Cl)N=CN3C)C |
| Reference | </br>1:Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol. 2014 Sep;86(3):342-57. doi: 10.1124/mol.114.093286. Epub 2014 Jun 23. PubMed PMID: 24958817; PubMed Central PMCID: PMC4152908.</br>2:Lam J, Coleman N, Garing AL, Wulff H. The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases. Expert Opin Ther Targets. 2013 Oct;17(10):1203-20. doi: 10.1517/14728222.2013.823161. Epub 2013 Jul 25. Review. PubMed PMID: 23883298; PubMed Central PMCID: PMC3778119.</br>3:Kasumu AW, Hougaard C, Rode F, Jacobsen TA, Sabatier JM, Eriksen BL, Strøbæk D, Liang X, Egorova P, Vorontsova D, Christophersen P, Rønn LC, Bezprozvanny I. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53. doi: 10.1016/j.chembiol.2012.07.013. PubMed PMID: 23102227; PubMed Central PMCID: PMC3483567. |
