For research use only. Not for therapeutic Use.
NS1652（Cat No.:I020370） is a reversible inhibitor of anion conductance, specifically targeting chloride channels found in both human and mouse erythrocytes. Its inhibitory action is characterized by an IC50 (half-maximal inhibitory concentration) value of 1.6 μM, signifying its potency in blocking chloride channel activity. By interfering with these channels, NS1652 effectively modulates the transport of chloride ions across erythrocyte membranes. This inhibition may have implications in various physiological processes, making NS1652 a valuable tool for ion channel physiology research and a potential candidate for the development of therapies targeting diseases associated with aberrant chloride channel function.
| Catalog Number | I020370 |
| CAS Number | 1566-81-0 |
| Molecular Formula | C₁₅H₁₁F₃N₂O₃ |
| Purity | ≥95% |
| Target | Chloride Channel |
| Storage | Store at -20°C |
| IUPAC Name | 2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid |
| InChI | InChI=1S/C15H11F3N2O3/c16-15(17,18)9-4-3-5-10(8-9)19-14(23)20-12-7-2-1-6-11(12)13(21)22/h1-8H,(H,21,22)(H2,19,20,23) |
| InChIKey | CTNQAPPDQTYTHM-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C(=O)O)NC(=O)NC2=CC=CC(=C2)C(F)(F)F |
| Reference | [1]. Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.<br>[2]. Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8. |
