For research use only. Not for therapeutic Use.
NS1738（Cat No.:I008361）is a selective positive allosteric modulator (PAM) of the α7 nicotinic acetylcholine receptor (nAChR), a receptor implicated in cognitive function, learning, and memory. By enhancing the receptor’s activity, NS1738 has shown potential in improving cognitive performance and exerting neuroprotective effects, making it a candidate for treating neurological conditions such as Alzheimer’s disease, schizophrenia, and other cognitive disorders. Preclinical studies have suggested that NS1738 could enhance synaptic plasticity and neurotransmission, but further clinical research is necessary to evaluate its safety, efficacy, and therapeutic potential in humans.
| Catalog Number | I008361 |
| CAS Number | 501684-93-1 |
| Synonyms | NS1738; NS 1738; NS-1738.;3-(5-chloro-2-hydroxyphenyl)-1-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| Molecular Formula | C14H9Cl2F3N2O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | 1-(5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| InChI | InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23) |
| InChIKey | OUDXRNQPVSMGDW-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl |
| Reference | </br>1:Cheng Q, Yakel JL. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. J Neurosci. 2014 Jan 1;34(1):124-33. doi: 10.1523/JNEUROSCI.2973-13.2014. PubMed PMID: 24381273; PubMed Central PMCID: PMC3866480.</br>2: Freitas K, Ghosh S, Ivy Carroll F, Lichtman AH, Imad Damaj M. Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models. Neuropharmacology. 2013 Feb;65:156-64. doi: 10.1016/j.neuropharm.2012.08.022. Epub 2012 Oct 16. PubMed PMID: 23079470; PubMed Central PMCID: PMC3521074. |
