For research use only. Not for therapeutic Use.
NS1738 is a α7 positive allosteric modulator.
| Catalog Number | I008361 |
| CAS Number | 501684-93-1 |
| Synonyms | NS1738; NS 1738; NS-1738.;3-(5-chloro-2-hydroxyphenyl)-1-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| Molecular Formula | C14H9Cl2F3N2O2 |
| Purity | ≥95% |
| Target | Nicotinic Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | 1-(5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| InChI | InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23) |
| InChIKey | OUDXRNQPVSMGDW-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl |
| Reference | </br>1:Cheng Q, Yakel JL. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. J Neurosci. 2014 Jan 1;34(1):124-33. doi: 10.1523/JNEUROSCI.2973-13.2014. PubMed PMID: 24381273; PubMed Central PMCID: PMC3866480.</br>2: Freitas K, Ghosh S, Ivy Carroll F, Lichtman AH, Imad Damaj M. Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models. Neuropharmacology. 2013 Feb;65:156-64. doi: 10.1016/j.neuropharm.2012.08.022. Epub 2012 Oct 16. PubMed PMID: 23079470; PubMed Central PMCID: PMC3521074. |
