For research use only. Not for therapeutic Use.
NS2B/NS3-IN-3 hydrochlorideis an inhibitor of Flavivirus NS2B-NS3 protease[1].
NS2B/NS3-IN-3 hydrochloride (Compd 66) exhibits a strong antiviral activity against cellular replication of Zika virus in cells with EC68 values of 1-3 μM[1].
| Catalog Number | I040625 |
| CAS Number | 2832876-91-0 |
| Synonyms | 6-(furan-3-yl)-N-(piperidin-4-ylmethyl)-1H-indole-2-carboxamide;hydrochloride |
| Molecular Formula | C19H22ClN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H21N3O2.ClH/c23-19(21-11-13-3-6-20-7-4-13)18-10-15-2-1-14(9-17(15)22-18)16-5-8-24-12-16;/h1-2,5,8-10,12-13,20,22H,3-4,6-7,11H2,(H,21,23);1H |
| InChIKey | ILKRKFAPUXCGDZ-UHFFFAOYSA-N |
| SMILES | C1CNCCC1CNC(=O)C2=CC3=C(N2)C=C(C=C3)C4=COC=C4.Cl |
| Reference | [1]. Shenyou Nie, et al. Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease. Eur J Med Chem. 2021 Dec 5;225:113767. |
