NSC 15364

• CAT Number: I015428
• CAS Number: 4550-72-5
• Molecular Formula: C₁₃H₁₄N₄O
• Molecular Weight: 242.28
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1,3-bis(4-aminophenyl)urea
• InChI: InChI=1S/C13H14N4O/c14-9-1-5-11(6-2-9)16-13(18)17-12-7-3-10(15)4-8-12/h1-8H,14-15H2,(H2,16,17,18)
• InChIKey: MAPWYRGGJSHAAU-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1N)NC(=O)NC2=CC=C(C=C2)N

NSC 15364 (Cat No.:I015428) is a compound that inhibits apoptosis by directly interacting with VDAC1 and preventing its oligomerization. This mechanism of action also leads to the inhibition of apoptosis.

Reference

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.