NSC 185058

• CAT Number: I019299
• CAS Number: 39122-38-8
• Molecular Formula: C₁₁H₉N₃S
• Molecular Weight: 215.27
• Purity: ≥95%
• Target: Autophagy
• IUPAC Name: N-pyridin-2-ylpyridine-2-carbothioamide
• InChI: InChI=1S/C11H9N3S/c15-11(9-5-1-3-7-12-9)14-10-6-2-4-8-13-10/h1-8H,(H,13,14,15)
• InChIKey: UGWOJXZJIZUKDP-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)C(=S)NC2=CC=CC=N2

NSC 185058(CAT: I019299) is a selective inhibitor of ATG4B, a critical cysteine protease involved in autophagy regulation. By antagonizing ATG4B, NSC 185058 attenuates autophagic activity by impairing ATG8 processing and autophagosome formation. This compound is particularly valuable in oncology and autophagy research, demonstrating efficacy in reducing glioblastoma (GBM) cell tumorigenicity. Furthermore, NSC 185058 enhances the anti-tumor effects of radiation therapy (RT) in orthotopic GBM xenograft models, highlighting its potential as a therapeutic adjuvant. NSC 185058 is a powerful tool for exploring autophagy-related mechanisms and developing innovative cancer treatment strategies.