NSC 23766 trihydrochloride

• CAT Number: I000633
• CAS Number: 1177865-17-6
• Molecular Formula: C24H35N7 • 3HCl
• Molecular Weight: 531.00
• Purity: ≥95%
• Synonyms: 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine
• Target: Rho
• Solubility: DMSO: ≤ 7.6 mg/mL
• Storage: 3 years -20C powder
• IC50: 50 uM
• IUPAC Name: 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine;trihydrochloride
• InChI: InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
• InChIKey: CPUHORIUXPQCHW-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl

NSC 23766 Trihydrochloride（Cat No.:I000633）is a selective inhibitor of the Rac1 GTPase, which plays a key role in various cellular processes, including cell migration, proliferation, and cytoskeletal organization. By specifically blocking Rac1 signaling, NSC 23766 trihydrochloride inhibits Rac1-mediated pathways without affecting related GTPases like RhoA or Cdc42. It has been widely used in research to study Rac1’s role in cancer, cardiovascular diseases, and neurodegenerative disorders. Its ability to modulate cell movement and growth makes it a valuable tool in investigating treatments targeting Rac1-driven pathologies.

Reference

[1]. Gao Y, et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A, 2004, 101(20), 7618-7623.
[2]. Akbar H, et al. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol, 2006, 406, 554-565.
[3]. Sawada N, et al. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res, 2008, 103(4), 360-368.
[4]. Yao HY, et al. Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice. Biochim Biophys Acta, 2011, 1810(7):666-674.