NSC-348884

• CAT Number: I004960
• CAS Number: 81624-55-7
• Molecular Formula: C₃₈H₄₀N₁₀
• Molecular Weight: 636.8
• Purity: ≥95%
• Synonyms: N1,N1,N2,N2-tetrakis((6-methyl-1H-benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine
• Target: Apoptosis
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: 2-8°C
• IUPAC Name: N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
• InChI: InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)
• InChIKey: KZOLQEUQAFTQFM-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C

NSC348884（Cat No.:I004960） is a potent inhibitor of nucleophosmin, a protein involved in various cellular processes. This compound disrupts the oligomer formation of nucleophosmin, leading to the induction of apoptosis and inhibition of cell proliferation. It exhibits an IC50 range of 1.7-4.0 μM in different cancer cell lines, indicating its potential as an anticancer agent.

Reference

[1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20.