NSC 405020

• CAT Number: I000060
• CAS Number: 7497-07-6
• Molecular Formula: C₁₂H₁₅Cl₂NO
• Molecular Weight: 260.16
• Purity: ≥95%
• Synonyms: 3,4-dichloro-N-pentan-2-ylbenzamide
• Target: MMP
• Solubility: 10 mM in DMSO
• Storage: Store at RT
• IC50: > 100 uM [1]
• InChI: InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
• InChIKey: ARDYECYBETXQFD-UHFFFAOYSA-N
• SMILES: CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl

NSC 405020(CAT: I000060) is a small molecule inhibitor that specifically disrupts the interaction between the protein NEMO (NF-κB essential modulator) and ubiquitin chains. It is widely utilized in immunology and cancer research for its ability to modulate the NF-κB signaling pathway. By interfering with NEMO’s binding to ubiquitin, NSC 405020 inhibits the activation of NF-κB, a key regulator of inflammation, immune responses, and cell survival. Researchers use this compound to investigate therapeutic strategies for diseases driven by dysregulated NF-κB activity, including cancer, autoimmune disorders, and chronic inflammatory conditions. Its specificity and mechanism of action make it a valuable tool for preclinical studies targeting NF-κB signaling.