For research use only. Not for therapeutic Use.
NSC-60339（Cat No.:I015551）is a potent small molecule inhibitor that targets the c-Met receptor (also known as hepatocyte growth factor receptor), which plays a critical role in tumor growth, metastasis, and angiogenesis. By inhibiting c-Met signaling, NSC-60339 shows promise in treating cancers that exhibit aberrant c-Met activation, including lung, gastric, and colorectal cancers. Its ability to block the c-Met pathway could reduce tumor progression and enhance the efficacy of existing therapies. Research into its mechanisms continues, with potential applications in targeted cancer therapies.
| Catalog Number | I015551 |
| CAS Number | 70-09-7 |
| Molecular Formula | C₂₆H₂₃ClN₆O₂ |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | Store at -20°C |
| IUPAC Name | 2-chloro-1-N,4-N-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide |
| InChI | InChI=1S/C26H23ClN6O2/c27-22-15-18(25(34)32-19-6-1-16(2-7-19)23-28-11-12-29-23)5-10-21(22)26(35)33-20-8-3-17(4-9-20)24-30-13-14-31-24/h1-10,15H,11-14H2,(H,28,29)(H,30,31)(H,32,34)(H,33,35) |
| InChIKey | UJQGBYRKCZQJJS-UHFFFAOYSA-N |
| SMILES | C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C3=CC(=C(C=C3)C(=O)NC4=CC=C(C=C4)C5=NCCN5)Cl |
| Reference | [1]. D. W. Yesair, et al. Relationship of Phthalanilide-Lipid Complexes to Uptake and Retention of 2-Chloro-4′,4″-di(2-imidazolin-2-yl)terephthalanilide (NSC 60339) by Sensitive and Resistant P388 Leukemia Cells. CANCER RESEARCH 26 Part 1: 202-207, February 1966.<br>[2]. Yesair DW, et al. The retention or efflux of phthalanilide (NSC 60339)-lipid complexes by sensitive or resistant murine tumor cells and Escherichia coli B. Cancer Res. 1968 Feb;28(2):314-9.<br>[3]. Haynes KM, et al. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. J Med Chem. 2017 Jul 27;60(14):6205-6219.<br>[4]. Abdali N, et al. Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump. ACS Infect Dis. 2017 Jan 13;3(1):89-98. |
