For research use only. Not for therapeutic Use.
NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity[1].
NSC 689534/Cu2+ complex (48 h) inhibits cell viability of HL60 and PC3 cell with IC50s of 0.2 and 0.4 μM respectively, which is about 4 times more potent than NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces oxidative stress and depletes GSH in PC3 cells, whereas with no effect by NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces macroautophagy (indicated by LC3 accumulation into large autophagosomes) and an ER-stress response (upregulation of GRP78 and CHOP) in PC3 cells[1].
NSC 689534/Cu2+ complex (3 mg/kg, i.p., once or twice a day for 5 days) inhibits tumor growth in HL60 xenograft model, whereas with no statistical significance by NSC 689534 alone[1].
| Catalog Number | I040169 |
| CAS Number | 907958-80-9 |
| Synonyms | 1,1-bis(pyridin-2-ylmethyl)-3-[(E)-pyridin-2-ylmethylideneamino]thiourea |
| Molecular Formula | C19H18N6S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H18N6S/c26-19(24-23-13-16-7-1-4-10-20-16)25(14-17-8-2-5-11-21-17)15-18-9-3-6-12-22-18/h1-13H,14-15H2,(H,24,26)/b23-13+ |
| InChIKey | AEEZWHXVVXFVAD-YDZHTSKRSA-N |
| SMILES | C1=CC=NC(=C1)CN(CC2=CC=CC=N2)C(=S)NN=CC3=CC=CC=N3 |
| Reference | [1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. |
