For research use only. Not for therapeutic Use.
NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 µM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells[1].
NSC 694621 (25 µM; 72 h) exhibits antiproliferative effect to SK-N-SH and HCT116 cells[1].
| Catalog Number | I043399 |
| CAS Number | 104857-29-6 |
| Synonyms | 2-(4-methoxyphenyl)-[1,2]thiazolo[5,4-b]pyridin-3-one |
| Molecular Formula | C13H10N2O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H10N2O2S/c1-17-10-6-4-9(5-7-10)15-13(16)11-3-2-8-14-12(11)18-15/h2-8H,1H3 |
| InChIKey | AZVIMHSUSDTTCB-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)N2C(=O)C3=C(S2)N=CC=C3 |
| Reference | [1]. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. |
