For research use only. Not for therapeutic Use.
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer[1].
NSC 694623 has antiproliferative activity against SK-N-SH with an IC50 of 8.93 μM, and inhibits 21% of HCT116 at 25 μM[1].
| Catalog Number | I043398 |
| CAS Number | 907957-34-0 |
| Synonyms | 2-(4-butylphenyl)-[1,2]thiazolo[5,4-b]pyridin-3-one |
| Molecular Formula | C16H16N2OS |
| Purity | ≥95% |
| InChI | InChI=1S/C16H16N2OS/c1-2-3-5-12-7-9-13(10-8-12)18-16(19)14-6-4-11-17-15(14)20-18/h4,6-11H,2-3,5H2,1H3 |
| InChIKey | XNGPPEMGIZDPGJ-UHFFFAOYSA-N |
| SMILES | CCCCC1=CC=C(C=C1)N2C(=O)C3=C(S2)N=CC=C3 |
| Reference | [1]. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. |
