NSC-697923

• CAT Number: R060812
• CAS Number: 343351-67-7
• Molecular Formula: C11H9NO5S
• Molecular Weight: 267.26
• Purity: ≥95%
• Synonyms: 2-[(4-Methylphenyl)sulfonyl]-5-nitro-furan
• Target: E2 conjugating
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20 C
• IUPAC Name: 2-(4-methylphenyl)sulfonyl-5-nitrofuran
• InChI: InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
• InChIKey: GAUHIPWCDXOLCZ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]

NSC-697923（Cat No.:R060812）is a selective inhibitor of the ubiquitin-conjugating enzyme Ubc13, which plays a key role in the ubiquitination process involved in cellular signaling and DNA damage repair. By targeting Ubc13, NSC-697923 disrupts the formation of polyubiquitin chains, leading to impaired NF-κB activation and reduced inflammatory responses. This compound has shown potential in preclinical studies for its anticancer properties, particularly in promoting apoptosis in cancer cells with defective DNA repair mechanisms. NSC-697923 is an important tool for studying ubiquitination pathways and exploring therapeutic approaches in cancer treatment.