For research use only. Not for therapeutic Use.
NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage[1].
NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving[1].
| Catalog Number | I044653 |
| CAS Number | 101982-51-8 |
| Synonyms | 2-methyl-1-(2-methylpropyl)-3-[2-(4-nitrophenyl)-2-oxoethyl]benzo[f]benzimidazol-3-ium-4,9-dione;bromide |
| Molecular Formula | C24H22BrN3O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H22N3O5.BrH/c1-14(2)12-25-15(3)26(13-20(28)16-8-10-17(11-9-16)27(31)32)22-21(25)23(29)18-6-4-5-7-19(18)24(22)30;/h4-11,14H,12-13H2,1-3H3;1H/q+1;/p-1 |
| InChIKey | SDVDJIZVNFVMLG-UHFFFAOYSA-M |
| SMILES | CC1=[N+](C2=C(N1CC(C)C)C(=O)C3=CC=CC=C3C2=O)CC(=O)C4=CC=C(C=C4)[N+](=O)[O-].[Br-] |
| Reference | [1]. Glaros TG, et al. The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212. |
