For research use only. Not for therapeutic Use.
NSC-87877（Cat No.:R042372）is a selective inhibitor of the SHP2 and RasGAP proteins, key regulators in the RAS/ERK signaling pathway. By inhibiting these proteins, NSC-87877 blocks the dephosphorylation of certain signaling molecules, affecting pathways related to cell growth, survival, and differentiation. It has been widely used in cancer research, particularly in studying tumors driven by aberrant RAS signaling. NSC-87877 is valuable for investigating therapeutic strategies that target RAS-driven cancers and other conditions where SHP2 plays a critical role, such as neurodevelopmental disorders and immune-related diseases.
| Catalog Number | R042372 |
| CAS Number | 56990-57-9 |
| Synonyms | 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic Acid |
| Molecular Formula | C₁₉H₁₃N₃O₇S₂ |
| Purity | ≥95% |
| Target | Protein Ser/Thr Phosphatases |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at 4°C |
| IUPAC Name | 8-hydroxy-7-[(6-sulfonaphthalen-2-yl)diazenyl]quinoline-5-sulfonic acid |
| InChI | InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29) |
| InChIKey | XGMFVZOKHBRUTL-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C(C(=C2N=C1)O)N=NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)S(=O)(=O)O |
| Reference | </br>1:NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Shi Y, Ma IT, Patel RH, Shang X, Chen Z, Zhao Y, Cheng J, Fan Y, Rojas Y, Barbieri E, Chen Z, Yu Y, Jin J, Kim ES, Shohet JM, Vasudevan SA, Yang J.Cell Death Dis. 2015 Aug 6;6:e1841. doi: 10.1038/cddis.2015.207. PMID: 26247726 Free PMC Article</br>2:NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Song M, Park JE, Park SG, Lee DH, Choi HK, Park BC, Ryu SE, Kim JH, Cho S.Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. doi: 10.1016/j.bbrc.2009.02.069. Epub 2009 Feb 20. PMID: 19233143 |
