NSC 95397

• CAT Number: I010430
• CAS Number: 93718-83-3
• Molecular Formula: C14H14O4S2
• Molecular Weight: 310.38
• Purity: ≥95%
• Synonyms: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
• Target: Protein Ser/Thr Phosphatases
• Solubility: Soluble to 50 mM in DMSO and to 5 mM in ethanol
• Storage: -20°C
• IUPAC Name: 2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione
• InChI: InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
• InChIKey: MAASHDQFQDDECQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO

NSC 95397（Cat No.:I010430）is a potent dual inhibitor of Cdc25 phosphatases and the checkpoint kinase Chk1, both key regulators of cell cycle progression and DNA damage response. By inhibiting these enzymes, NSC 95397 disrupts cell cycle regulation, leading to cell cycle arrest and apoptosis in rapidly dividing cells, such as cancer cells. This compound has demonstrated potential in preclinical cancer research, particularly in sensitizing tumors to chemotherapy and radiation therapy. NSC 95397 offers a valuable tool for studying cell cycle regulation and exploring novel cancer treatment strategies.