NSC117079

• CAT Number: I020225
• CAS Number: 500363-63-3
• Molecular Formula: C₂₀H₁₅N₃O₇S₂
• Molecular Weight: 473.48
• Purity: ≥95%
• Target: Phosphatase
• IUPAC Name: 1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid
• InChI: InChI=1S/C20H15N3O7S2/c21-18-15(32(28,29)30)9-14(23-10-4-3-5-11(8-10)31(22,26)27)16-17(18)20(25)13-7-2-1-6-12(13)19(16)24/h1-9,23H,21H2,(H2,22,26,27)(H,28,29,30)
• InChIKey: LHSBZAWDPSTOEY-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3NC4=CC(=CC=C4)S(=O)(=O)N)S(=O)(=O)O)N

NSC117079(CAT: I020225) is a novel and selective PHLPP (PH domain leucine-rich repeat protein phosphatase) inhibitor that effectively prevents the dephosphorylation of Akt, a critical kinase involved in cell survival and immune responses. At a concentration of 30 μM, NSC117079 significantly increases neutrophil adhesion to fibrinogen-coated surfaces from 9.0±2.4% to 27.0±8.0% and further enhances adhesion induced by 50 ng/mL GM-CSF from 22.9±6.0% to 47.6±10.9%. However, it does not affect neutrophil transendothelial migration. This suggests that PHLPP plays a key role in regulating neutrophil adhesion via Akt signaling, making NSC117079 valuable in inflammation and immune response research.