For research use only. Not for therapeutic Use.
NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM. NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc. Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation.
KEYWORDS: NSC194598 | supplier | p53 inhibitor | NSC 194598 | NSC-194598 | CAS [5358-76-9] | [5358-77-0] | Non Selective | p53 | Inhibitor | Transcription Factors | Alzheimer’s disease | Parkinson’s disease | Stroke | Radiation | Chemotherapy
| Catalog Number | I047661 |
| CAS Number | 5358-76-9 |
| Molecular Formula | C20H19N3O |
| Purity | ≥95% |
| IUPAC Name | 2-oxido-3-(piperidin-1-ylmethyl)-4-aza-2-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-1,3,5,7,9(16),10,12,14-octaene |
| InChI | InChI=1S/C20H19N3O/c24-23-18(13-22-11-4-1-5-12-22)21-17-10-6-9-15-14-7-2-3-8-16(14)20(23)19(15)17/h2-3,6-10H,1,4-5,11-13H2 |
| SMILES | C1CCN(CC1)CC2=NC3=CC=CC4=C3C(=[N+]2[O-])C5=CC=CC=C45 |
| Reference | Q Li et al. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul;39(29):5187-5200. |
