NSC22494

• CAT Number: I033579
• CAS Number: 7152-40-1
• Molecular Formula: C12H9N5
• Molecular Weight: 223.23
• Purity: 98%
• Synonyms: NSC22494; NSC 22494; NSC-22494
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-amino-3-(cyanomethyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• InChI: InChI=1S/C12H9N5/c13-7-6-11-10(8-14)12(15)17(16-11)9-4-2-1-3-5-9/h1-5H,6,15H2
• InChIKey: GUHSDYKJSKLWJF-UHFFFAOYSA-N
• SMILES: Nc1n(c2ccccc2)nc(CC#N)c1C#N

NSC22494（Cat No.:I033579） is a biochemical compound that has been extensively studied for its inhibitory effects on the Wnt/β-catenin signaling pathway. This pathway plays a crucial role in various biological processes, including development, tissue homeostasis, and cancer progression. NSC22494 has been found to disrupt the interaction between β-catenin and TCF/LEF transcription factors, resulting in the inhibition of Wnt/β-catenin signaling. This compound has been used as a research tool to investigate the role of the Wnt pathway in cellular processes and to explore potential therapeutic applications in diseases associated with dysregulated Wnt signaling, such as cancer.